研究著作 (*表通訊作者) / Publication
  1. YA Hong, AA Khine, YW Lin, PY Lee, WX Hong, A Hu*, TL Shih*, HP Chen.* Metabolic engineering of the borneol and camphor degradation pathways in Pseudomonas to produce optically pure bicyclic monoterpenes. (2024) Enzyme and Microbial Technology 181: 110527. (https://doi.org/10.1016/j.enzmictec.2024.110527)
  2. Chen HC, You RI, Lin FM, Lin GL, Ho TJ*, Chen HP.* Novel therapeutic activities of dragon blood from palm tree Daemonorops draco for the treatment of chronic diabetic wounds. (2024) Botanical Studies  65 (1): 14. (https://doi.org/10.1186/s40529-024-00422-2)
  3. Hung YC, Chen LJ, Wang JH, Ho TJ, Tseng GF*, Chen HP.* The therapeutic potential of intraarticular injection of synthetic deer antler peptides in a rat model of knee osteoarthritis. (2024) International Journal of Molecular Sciences 25 (11): 6041. (https://doi.org/10.3390/ijms25116041​)
  4. Ho TJ, Tsai WT, Wu JR*, Chen HP.* Biological activities of deer antler-derived peptides on human chondrocyte and bone metabolism. (2024) Pharmaceuticals ​17 (4), 434. (https://doi.org/10.3390/ph17040434)
  5. Ching YH, Lin FM, Chen HC, Hsu CY, P'ng SY, Lin TN, Wang YC, Lin CJ, Chen YC, Ho TJ, Chen HP.* Hypoglycemic effects of dracorhodin and dragon blood crude extract from Daemonorops draco. (2024) Botanical Studies 65 (1): 8.  (https://doi.org/10.1186/s40529-024-00415-1)
  6. Ho TJ, Lin JH, Lin SZ, Tsai WT, Wu JR*, Chen HP.*  Isolation, identification, and characterization of bioactive peptides in human bone cells from tortoiseshell and deer antler gelatin. (2023) International Journal of Molecular Sciences  24 (2): 1759. (https://doi.org/10.3390/ijms24021759)
  7. Wu JR, Lu PC, Khine AA, Simaremare SR, Hung CC, Yiin LM, Ho TJ, Tung CH,* Chen HP.* Borneol dehydrogenase from Pseudomonas sp. TCU-HL1 possesses novel quinuclidinone reductase activities. (2023) Biocatalysis and Biotransformation 41 (1): 38-45.  (https://doi.org/10.1080/10242422.2021.1955865)
  8. Ho TJ, Tsai PH, Hsieh CH, Lin JH, Lin YW, Wu JR,* Chen HP.* Role of herbal extracts of catechu from Uncaria gambir in the treatment of chronic diabetic wounds. (2023) Pharmaceuticals 16 (1): 66. (https://doi.org/10.3390/ph16010066)
  9. Chen JK, Tsai WT, Lin SZ, Wang SH, Wang GC, Wang TC, Chen HP, Ho TJ.* Using radial pulse wave as hemodynamic measurements to quantify effects of acupuncture therapy for patients with traumatic brain injury and ischemia stroke. Journal of Traditional and Complementary Medicine (2022) 12 (6): 594-598. (https://doi.org/doi: 10.1016/j.jtcme.2022.08.005)
  10. Lai SC, You RI, Chen TT, Chang Y, Liu CZ, Chen HP,* Wu C.* Rapid identification of commercial frankincense products by MALDI-TOF mass spectrometry. (2022) Combinatorial Chemistry & High Throughput Screening  25 (5): 895-905.   (https://doi.org/10.2174/1386207324666210301092111)
  11. Wu JR, Lu YC, Hung SJ, Lin JH, Chang KC, Chen JK, Tasi WT, Ho TJ,* Chen HP.* Antimicrobial and immunomodulatory activity of herb extracts used in burn wound healing: “San Huang Powder”. (2021) Evidence-Based Complementary and Alternative Medicine, Volume 2021: 2900060. (https://doi.org/10.1155/2021/2900060)
  12. Lu CC, Yang CC, Chiu YJ, Tsai FJ, Hsu YM, Yin MC, Juan YN, Ho TJ,* Chen HP.* Dracorhodin perchlorate enhances wound healing via β-catenin, ERK/p38 and AKT signaling in human HaCaT keratinocytes. (2021) Experimental and Therapeutic Medicine 22 (2): 822. (https://doi.org/10.3892/etm.2021.10254)
  13. Hung SJ, Hong YA, Lin KY, Hua YW, Kuo CJ, Hu A,*, Shih TL,* Chen HP.* Efficient photodynamic killing of gram-positive bacteria by synthetic curcuminoids. (2020) International Journal of Molecular Sciences  21 (23): 9024. (https://doi.org/10.3390/ijms21239024)
  14. Khine AA, Lu PC, Ko TP, Huang KF, Chen HP.* Cloning, expression, identification and characterization of borneol dehydrogenase isozymes in Pseudomonas sp. TCU-HL1. (2020) Protein Expression and Purification 175: 105715. (https://doi.org/10.1016/j.pep.2020.105715)
  15. Tung CH, Lu YT, Kao WT, Liu JW, Lai YH, Jiang SJ, Chen HP,* Shih TL.* Discovery of a more potent anti-cancer agent than C4-benzazole 1,8-naphthalimide derivatives against murine melanoma. (2020) Journal of the Chinese Chemical Society 67 (7): 1254-1262.(https://doi.org/10.1002/jccs.202000019)
  16. Khine AA, Chen HP, Huang KF,* KO TP.* Structural characterization of borneol dehydrogenase from Pseudomonas sp. TCU-HL1. (2020) Acta Crystallographica Section F -Structural Biology Communications F76: 309-313. (https://doi.org/10.1107/S2053230X20008584)
  17. Khine AA, Yang MY, Hu A, Lin GH, Toh YH, Chen HP.* Production of optically pure (-)-borneol by Pseudomonas monteilii TCU-CK1 and characterization of borneol dehydrogenase involved. (2020) Enzyme and Microbial Technology 139: 109586.  (https://doi.org/10.1016/j.enzmictec.2020.109586)
  18. Ho TJ, Chen JK, Li TS, Lin JH, Hsu YH, Wu JR, Tsai WT, Chen HP.* The curative effects of the traditional Chinese herbal medicine “Jinchuang ointment” on excisional wounds. (2020) Chinese Medicine 15: 41. (https://doi.org/10.1186/s13020-020-00324-y)
  19. Hsu WH, Tsai WT, Hung SJ, Cheng HC, Hsu CH, Ho TJ,* Chen HP.* Treatment of leprosy wounds with “Jinchuang Ointment”, a traditional Chinese herbal medicine complex. (2019) Leprosy Review 90 (4):460-468. (https://doi.org/10.47276/lr.90.4.460​)
  20. Wu C, Cai XQ, Chang Y, Chen CH, Ho TJ, Lai SC, Chen HP.* Rapid identification of dragon blood samples from Daemonorops draco, Dracaena cinnabari and Dracaena cochinchinensis by MALDI-TOF mass spectrometry​. (2019) Phytochemical Analysis 30 (6): 720-726. (https://doi.org/10.1002/pca.2852)
  21. Krishnaraj P, Chang Y, Ho TJ, Lu NC, Lin MD,* Chen HP.* In vivo pro-angiogenic effects of dracorhodin perchlorate in zebrafish embryos: a novel bioactivity evaluation platform for commercial dragon blood samples. (2019) Journal of Food and Drug Analysis 27 (1): 259-265. (https://doi.org/10.1016/j.jfda.2018.08.005) 
  22. Yang MY, Khine AA, Liu JW, Cheng HC, Hu A,* Chen HP,* Shih TL.* Resolution of isoborneol and its isomers by GC/MS to identify “synthetic” and “semi-synthetic” borneol products. (2018) Chirality 30 (11): 1233-1239. (https://doi.org/10.1002/chir.23017)
  23. Ho TJ, Hung CC, Shih TL, Yiin LM,* Chen HP.* Investigation of borneols sold in Taiwan by chiral gas chromatography. (2018) Journal of Food and Drug Analysis 26 (1): 348-352. (https://doi.org/10.1016/j.jfda.2016.10.012)
  24. Tsang HL, Huang JL, Lin YH, Huang KF, Lu PL, Lin GH, Khine AA, Hu A, Chen HP.* Borneol dehydrogenase from Pseudomonas sp. strain TCU-HL1 catalyzes the oxidation of (+)-borneol and its isomers to camphor. (2016) Applied and Environmental Microbiology 82 (21): 6378-6385. (http://doi.org/10.1128/aem.01789-16)
  25. Ho TJ, Jiung SJ,* Lin GH, Li TS, Yiin LM, Yang JS, Hsieh MC, Wu CC, Lin JG, Chen HP.* The in vitro and in vivo wound healing properties of the Chinese herbal medicine “Jinchuang ointment. (2016) Evidence-Based Complementary and Alternative Medicine  Volume 2016: 1654056. (https://doi.org/10.1155/2016/1654056)
  26. Jin YA, Chiu YJ, Chen HP, Kuo DH, Lu CC, Yang JS.* Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical mesenchymal and bone marrow mesenchymal stem cells. (2016) Environmental Toxicology 31 (3): 314-28.
  27. Lin GH, Chen HP, Shu HY,* Detoxification of Indole by an Indole-Induced Flavoprotein Oxygenase from Acinetobacter baumannii. (2015) PLOS ONE 10 (9): e0138798. 
  28. Shu HY, Lin LC, Lin TK, Chen HP, Yang HH, Lin GH.* Transcriptional regulation of the iac locus from Acinetobacter baumannii by thephytohormone indole-3-acetic acid. (2015) Antonie van Leeuwenhoek 107 (5): 1237-1247.
  29. Lu CC, Chen HP, Chiang JH, Jin YA, Kuo SC, Wu TS, Hour MJ, Yang JS,* Chiu YJ. Quinazoline analog HMJ-30 inhibits angiogenesis: Involvement of endothelial cell apoptosis through ROS-JNK-mediated death receptor 5 signaling. (2014) Oncology Reports 32 (2): 597-606.
  30. Hsieh MT, Chen HP, Lu CC, Chiang JH, Wu TS, Kuo DH, Huang LJ, Kuo SC,* Yang JS.* The novel pterostilbene derivative ANK-199 induces autophagic cell death through regulating PI3 kinase class III/Beclin 1/Atg-related proteins in cisplatin-resistant human oral cancer CAR cells. (2014) International Journal of Oncology 45 (2): 782-794.
  31. Huang JH, Chen HP.* A novel capillary electrophoresis-based assay method for coenzyme B6-dependent diaminopimelate decarboxylase from Propionibacterium acnes. (2013) Analytical Methods 5 (5): 1279-1283.
  32. Chen HP, Zhu SH, Casabon I, Hallam SJ, Crocker FH, Mohn WW, Indest KJ,* Eltis LD.* Genomic and transcriptomic studies of an RDX-degrading actinobacterium. (2012) Applied and Environmental Microbiology 78 (21): 7798-7800.
  33. Chen HP, Chow M, Liu CC, Lau Al, Liu J, Eltis LD.* Vanillin catabolism in Rhodococcus jostii RHA1. (2012) Applied and Environmental Microbiology 78 (2): 586-588.
  34. Lin GH, Chen HP, Huang JH, Liu TT, Lin TK, Wang SJ, Tseng CH, Shu HY.*  Identification and characterization of an indigo-producing oxygenase involved in indole 3-acetic acid utilization by Acinetobacter baumannii. (2012) Antonie van Leeuwenhoek 101 (4): 881-890.
  35. Lin HJ, Hsu HJ, Duann YF, Chen HP.* Measurement of the Binding of Adenosylcobalamin to Glutamate Mutase by Fluorescence Spectroscopy. (2012) Journal of the Chinese Chemical Society 59 (11): 1478-1481.
  36. Indest KJ,* Jung CM, Chen HP, Hancock D, Florizone C, Eltis LD,* Crocker FH. Functional Characterization of pGKT2, a 182-Kilobase Plasmid Containing the xplABGenes, Which Are Involved in the Degradation of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine by Gordonia sp. Strain KTR9. (2010) Applied and Environmental Microbiology 76 (19): 6329-6337.
  37. Hsu CH,* Chen HP.* Molecular modeling studies of the conserved B12-binding motif and its variants from Clostridium tetanomorphum glutamate mutase. (2010) Protein & Peptide Letters 17 (6): 759-764.
  38. Chen HP,* Hsu HJ, Hsu FC, Lai CC, Hsu CH. The interactions between coenzyme B12 analogs and adenosylcobalamin-dependent glutamate mutase from Clostridium tetanomorphum. (2008) FEBS Journal 275 (23): 5960-5968.
  39. Tseng CH, Yang CH, Lin HJ, Wu C, Chen HP.* The S subunit of D-ornithine aminomutase from Clostridium sticklandii is responsible for the allosteric regulation in D-alpha-lysine aminomutase. (2007) FEMS Microbiology Letters 274 (1):148-153.
  40. Weng YP, Yang WS, Hsu FC, Chen HP.* Optimization of the overexpression of glutamate mutase S component under the control of T7 system by using lactose and IPTG as the inducers. (2006) Enzyme and Microbial Technology 38 (3-4): 465-469.
  41. Hsu FC, Ho TJ, Lai CC, Lin CF, Chen HP.* Cloning, sequencing, expression, and single-step purification of the adenosylcobinamide kinase/ adenosylcobinamide-phosphate guanylyltransferase (CobU) from Salmonella typhimurium ATCC 19585. (2005) Protein Expression and Purification 42 (1):178-181.
  42. Chen HP,* Hsu FC, Lin LY, Ren CT, Wu SH. Coexpression, purification, and characterization of the E and S subunits of coenzyme B12 and B6 dependent Clostridium sticklandii D-ornithine aminomutase in Escherichia coli. (2004) European Journal of Biochemistry 271 (21): 4293-4297.
  43. Chen HP,* Lung FD, Yeh CC, Chen HL, Wu SH. The role of the conserved histidine-aspartate pair in the ‘base-off’ binding of cobalamins. (2004) Bioorganic and Medicinal Chemistry 12 (3): 577-582.
  44. Chen HP,* Wu SH, Lin YL, Chen CM, Tsay SS. Cloning, sequencing, heterologous expression, purification and characterization of adenosylcobalamin-dependent D-ornithine aminomutase from Clostridium sticklandii. (2001) Journal of Biological Chemistry 276 (48): 44744-44750.
  45. Chen HP,* Lin CF, Lee YJ, Tsay SS, Wu SH. Purification and properties of ornithine racemase from Clostridium sticklandii. (2000) Journal of Bacteriology 182 (7): 2052-2054.
  46. Huhta MS, Chen HP, Hemann C, Hille CR, Marsh ENG.* Protein-coenzyme interactions in adenosylcobalamin-dependent glutamate mutase. (2001) Biochemical Journal 355 (Pt 1): 131-137.
  47. Roymoulik I, Chen HP, Marsh ENG.* The reaction of the substrate analog 2-Ketoglutarate with adenosylcobalamin-dependent glutamate mutase. (1999) Journal of Biological Chemistry 274 (17): 11619-11622.  
  48. Chen HP, Marsh ENG.* Adenosylcobalamin-dependent glutamate mutase: examination of substrate and coenzyme binding in an engineered fusion protein of possessing simplified subunit structure and kinetic properties. (1997) Biochemistry 36 (48): 14939-14945.
  49. Chen HP, Marsh  ENG.* How enzyme controls the reactivity of adenosylcobalamin: effect on coenzyme-bindng and catalysis of mutations in the conserved histidine-aspartate pair of glutamate mutase. (1997) Biochemistry 36 (25): 7884-7889.
  50. Holloway DE, Chen HP, Marsh ENG.* Carboxymethylation of MutS-cysteine-15 specificially inactivates adenosylcobalamin-dependent glutamate mutase-examination of the role of this residue in coenzyme-binding and catalysis. (1996) Journal of Biological Chemistry 271 (46): 29121-29125.
  51. Chen HP, Hsaio KF, Wu SH,* Wang KT. Regioselectivity enhancement by partial purification of lipase from Aspergillus niger.  (1995) Biotechnology Letters 17 (3): 305-308.
  52. Chen HP, Wu SH,* Wang KT. D-Aminoacylase from Alcaligenes faecalis possesses novel activities on D-Met. (1994) Bioorganic and Medicinal Chemistry 2 (1): 1-5.
  53. Chen HP, Wu SH,* Tsai YC, Yang YB, Wang KT. Enantioselective deprotection of N-protected amino acids by D-aminoacylase. (1992) Bioorganic and Medicinal Chemistry Letters 2 (7): 697-700.

中文散文 / Essay published in Chinese
  1. 陳灝平.* 從歷史與文化的觀點談中西醫藥的差異 (2024) 北台灣中醫醫學雜誌 16 (1): 1-18.
  2. 陸乃甄、賴尚志、何宗融、陳灝平.* 『乳香』的檢驗與活性分析-兼談『金創膏』在傷口照護的進展 (2022) 北台灣中醫醫學雜誌 14 (2): 17-32.
  3. 盧昱竹、吳家如、洪崧壬、林榮興、陳中奎、謝明穎、蔡婉婷、何宗融*、陳灝平* 中藥『三黃散』對燙傷的療效研究 (2021) 中醫藥研究論叢 24 (1): 9-23.
  4. ​陸乃甄、何宗融、林明德、Preethi Krishnaraj、賴尚志、陳灝平.* 談坊間市售血竭的種類與生物活性分析 (2019) 北台灣中醫醫學雜誌，11 (1): 1-11.
  5. 吳鐘霖、何宗融、吳炫璋、陳灝平.* 談中藥材『冰片』的分類、鏡像分析與歸經的感受 (2017) 北台灣中醫醫學雜誌，9 (1): 23-33.
  6. 何宗融、陳灝平.* 談中藥『金創膏』於慢性不癒合傷口的治療及生物活性分析 (2016) 北台灣中醫醫學雜誌，8 (2): 13-20.

專利 / Patents
  1. 許鴻猷、林光慧、陳灝平。 一種檢測鮑氏不動桿菌之方法及其使用之試劑。中華民國發明專利，專利號碼: 1673364。
  2. 陳灝平。食樹脂假單胞菌、冰片脫氫酶、含其之混合物、及其應用。中華民國發明專利，專利號碼: 108111234。
  3. 胡安仁、洪崧仁、施增廉、陳灝平。殺菌劑及其用途。中華民國發明專利，專利號碼: 109131334。
  4. 陳灝平。食樹脂假單胞菌、冰片脫氫酶、含其之混合物、及其應用。中華人民共和國發明專利，專利號碼: ZL 2019 1 0253002.4。
  5. 胡安仁、洪崧仁、施增廉、陳灝平。殺菌劑及殺菌方法。。中華人民共和國發明專利，專利號碼: ZL 2020 8 0102727.4。

獲獎 / Prize
   1. 2024年第21屆國家新創獎『高藻膽蛋白葛仙米的栽培與生醫應用』。
   2. 2024年第21屆國家新創精進獎『治療或是預防骨質疏鬆與膝關節炎的鹿角胜肽』。
   3. 2023年第20屆國家新創獎『治療或是預防骨質疏鬆與膝關節炎的鹿角胜肽』。
   4. 2022年第19屆國家新創獎『環保活性螢光生物材料』。

資料庫 / Database
  1. Chen HP.* (2019) "Pseudomonas monteilii strain TCU-CK1 chromosome, complete genome." NCBI GenBank Database, Accession Number: CP040324.
  2. Chen HP,* Huang JL, Lin YH, (2016) "Complete genome sequence of Pseudomonas sp. TCU-HL1." NCBI GenBank Database, Accession Number: CP015992, CP015993.
  3. Chen HP, Lau A, Davis AE, Zhu S, Eng SWM, Howes CG, Crocker FH, Indest KJ, Hallam SJ, Eltis LD,* (2011) “Complete genome sequence of Gordonia sp. KTR9.” NCBI GenBank Database, Accession Number: CP002907, CP002908, CP002909.